Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group.
نویسندگان
چکیده
A removable protecting group has been identified that allows the products of widely-used cross dehydrogenative couplings to be synthetically elaborated. The method can be used with enantiopure amines with no loss of enantiomeric excess. The methodology is exemplified by a new synthesis of enantiopure praziquantel, the drug used in the treatment of millions of people suffering from the neglected tropical disease, schistosomiasis.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 30 شماره
صفحات -
تاریخ انتشار 2013